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Besides an increased homocysteine export from tissues into plasma that may be regulated by a reduced-homocysteine carrier (Blom, 2000), hyperhomocysteinemia can result from reduced renal function, which may have a central role in plasma homocysteine clearance, and from chronic hepatic insufficiency

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Evidence level is high based on confirmed Phase 3 data

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Reconstitution math: choosing your concentration The formula is simple: Concentration (mg/ml) = Total peptide (mg) / Volume of water added (ml) So if you have a 30 mg vial and add 3 ml of bacteriostatic water, your concentration is 30/3 = 10 mg/ml